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Article

Malignant transformation of polyostotic fibrous dysplasia with aberrant keratin expression.

Human pathology - 1 Apr 2017

Zreik Riyam T, Littrell Laurel A, Jin Long, Oliveira Andre M, Fritchie Karen J

Abstract excerpt

Malignant transformation of fibrous dysplasia (FD) is exceedingly rare, occurring in less than 1% of all FD cases, and has been described in both monostotic and polyostotic forms of this entity. We report a case of a large proximal femur mass arising in a 45-year-old man. The biopsy revealed a high-grade pleomorphic malignancy that focally expressed multiple keratins. Based on the presence of keratin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Fibrous Dysplasia, Polyostotic

Share to GTP-Binding Protein alpha Subunits, Gs

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Source

Identifiers

PMID: 27771377
DOI: 10.1016/j.humpath.2016.09.030

Genes

GNAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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