Evaluation of the EGFR polymorphism R497K in two cohorts of neoadjuvantly treated breast cancer patients.

doi:10.1371/journal.pone.0189750

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Article

Evaluation of the EGFR polymorphism R497K in two cohorts of neoadjuvantly treated breast cancer patients.

PloS one - 1 Jan 2017

Sobral-Leite Marcelo, Lips Esther H, Vieira-Monteiro Hayra de Andrade, Giacomin Letícia Carlos, Freitas-Alves Daniely Regina, Cornelissen Sten, Mulder Lennart, Wesseling Jelle, Schmidt Marjanka K, Vianna-Jorge Rosane

Abstract excerpt

Pathological response of breast cancer to neoadjuvant chemotherapy (NAC) presents great variability, and new prognostic biomarkers are needed. Our aim was to evaluate the association of the epidermal growth factor receptor gene (EGFR) polymorphism R497K (rs2227983) with prognostic features and clinical outcomes of breast cancer, including the pathological response to NAC and the recurrence-free survival (RFS)....

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PMID: 29267323
DOI: 10.1371/journal.pone.0189750
PMCID: PMC5739423

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EGFR

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