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Article

Stem cells, senescence, neosis and self-renewal in cancer.

1 Jan 2006

Abstract excerpt

We describe the basic tenets of the current concepts of cancer biology, and review the recent advances on the suppressor role of senescence in tumor growth and the breakdown of this barrier during the origin of tumor growth. Senescence phenotype can be induced by (1) telomere attrition-induced senescence at the end of the cellular mitotic life span (MLS*) and (2) also by replication history-independent,...

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PMID: 17092342
DOI: 10.1186/1475-2867-6-25

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