Article
Reduced LRRK2 in association with retromer dysfunction in post-mortem brain tissue from LRRK2 mutation carriers.
Brain : a journal of neurology - 1 Feb 2018
Zhao Ye, Perera Gayathri, Takahashi-Fujigasaki Junko, Mash Deborah C, Vonsattel Jean Paul G, Uchino Akiko, Hasegawa Kazuko, Jeremy Nichols R, Holton Janice L, Murayama Shigeo, Dzamko Nicolas, Halliday Glenda M
Abstract excerpt
Missense mutations in leucine-rich repeat kinase 2 (LRRK2) are pathogenic for familial Parkinson's disease. However, it is unknown whether levels of LRRK2 protein in the brain are altered in patients with LRRK2-associated Parkinson's disease. Because LRRK2 mutations are relatively rare, accounting for approximately 1% of all Parkinson's disease, we accessioned cases from five international brain banks to...
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