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Article

Cyclophilin A is required for efficient human cytomegalovirus DNA replication and reactivation

12 Jan 2012

Abstract excerpt

Human cytomegalovirus (HCMV) is a large DNA virus belonging to the subfamily Betaherpesvirinae. Haematopoietic cells of the myeloid lineage have been shown to harbour latent HCMV. However, following terminal differentiation of these cells, virus is reactivated, and in an immunocompromised host acute infection can occur. It is currently unknown which viral and cellular factors are involved in regulating the switch...

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PMID: 22238232
DOI: 10.1099/vir.0.037309-0

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