Article
Hereditary cancer syndromes as model systems for chemopreventive agent development.
Seminars in oncology - 1 Feb 2016
Walcott Farzana L, Patel Jigar, Lubet Ronald, Rodriguez Luz, Calzone Kathleen A
Abstract excerpt
Research in chemoprevention has undergone a shift in emphasis for pragmatic reasons from large, phase III randomized studies to earlier phase studies focused on safety, mechanisms, and utilization of surrogate endpoints such as biomarkers instead of cancer incidence. This transition permits trials to be conducted in smaller populations and at substantially reduced costs while still yielding valuable information....
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