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Article

CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia.

Cell death & disease - 10 Oct 2013

Di Pasquale E, Lodola F, Miragoli M, Denegri M, Avelino-Cruz J E, Buonocore M, Nakahama H, Portararo P, Bloise R, Napolitano C, Condorelli G, Priori S G

Abstract excerpt

Induced pluripotent stem cells (iPSC) offer a unique opportunity for developmental studies, disease modeling and regenerative medicine approaches in humans. The aim of our study was to create an in vitro 'patient-specific cell-based system' that could facilitate the screening of new therapeutic molecules for the treatment of catecholaminergic polymorphic ventricular tachycardia (CPVT), an inherited form of fatal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium-Calmodulin-Dependent Protein Kinase Type 2

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Share to Receptors, Adrenergic, beta

Share to Ryanodine Receptor Calcium Release Channel

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Share to Tachycardia, Ventricular

Source

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Identifiers

PMID: 24113177
DOI: 10.1038/cddis.2013.369
PMCID: PMC3824678

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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