Article
The gene-treatment interaction of paraoxonase-1 gene polymorphism and statin therapy on insulin secretion in Japanese patients with type 2 diabetes: Fukuoka diabetes registry.
BMC medical genetics - 12 Dec 2017
Sumi Akiko, Nakamura Udai, Iwase Masanori, Fujii Hiroki, Ohkuma Toshiaki, Ide Hitoshi, Jodai-Kitamura Tamaki, Komorita Yuji, Yoshinari Masahito, Hirakawa Yoichiro, Hirano Atsushi, Kubo Michiaki, Kitazono Takanari
Abstract excerpt
BACKGROUND: Although statins deteriorate glucose metabolism, their glucose-lowering effects have emerged in some situations. Here, we assessed whether these effects are a consequence of statins' interaction with paraoxonase (PON)1 enzyme polymorphism. METHODS: Adult Japanese type 2 diabetes patients (n = 3798) were enrolled in a cross-sectional study. We used Q192R polymorphism of the PON1 gene as a...
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