Article
Association of paraoxonase-1 gene polymorphisms with insulin resistance in South Indian population.
Gene - 15 Apr 2018
Gomathi Panneerselvam, Iyer Anandi Chandramouli, Murugan Ponniah Senthil, Sasikumar Sundaresan, Raj Nancy Bright Arul Joseph, Ganesan Divya, Nallaperumal Sivagnanam, Murugan Maruthamuthu, Selvam Govindan Sadasivam
Abstract excerpt
BACKGROUND AND AIM: Insulin resistance plays a crucial role in the pathogenesis of type 2 diabetes and cardiovascular diseases. Recently, paraoxonase-1(PON1) is reported to have an ability to reduce insulin resistance by promoting glucose transporter-4 (GLUT-4) expression in vitro. Single nucleotide polymorphism (SNP) in PON1 is associated with variability in enzyme activity and concentration. Based on this we...
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