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Article

Association of the asporin D14 allele with lumbar-disc degeneration in Asians.

American journal of human genetics - 1 Mar 2008

Song You-Qiang, Cheung Kenneth M C, Ho Daniel W H, Poon Sandy C S, Chiba Kazuhiro, Kawaguchi Yoshiharu, Hirose Yuichiro, Alini Mauro, Grad Sibylle, Yee Anita F Y, Leong John C Y, Luk Keith D K, Yip Shea-Ping, Karppinen Jaro, Cheah Kathryn S E, Sham Pak, Ikegawa Shiro, Chan Danny

Abstract excerpt

Lumbar-disc degeneration (LDD) is a polygenic disease. Susceptibility genes reported so far are mainly extracellular matrix proteins. D14 allele of asporin (ASPN) is associated with osteoarthritis (OA). Candidate-gene association studies showed that the D14 allele is also significantly associated with LDD in Chinese and Japanese individuals. Meta-analysis showed that individuals harboring a D14 allele had higher...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18304494
DOI: 10.1016/j.ajhg.2007.12.017
PMCID: PMC2427233

Genes

ASPN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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