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Article

Activation of the Aryl Hydrocarbon Receptor Leads to Resistance to EGFR TKIs in Non-Small Cell Lung Cancer by Activating Src-mediated Bypass Signaling.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2018

Ye Mingxiang, Zhang Yong, Gao Hongjun, Xu Yan, Jing Pengyu, Wu Jianxiong, Zhang Xinxin, Xiong Jie, Dong Chenfang, Yao Libo, Zhang Jian, Zhang Jian

Abstract excerpt

Purpose: The aryl hydrocarbon receptor (AhR) has been generally recognized as a ligand-activated transcriptional factor that responds to xenobiotic chemicals. Recent studies have suggested that the expression of AhR varies widely across different cancer types and cancer cell lines, but its significance in cancer treatment has yet to be clarified.Experimental Design: AhR expression in non-small cell lung cancer...

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Identifiers

PMID: 29229632
DOI: 10.1158/1078-0432.CCR-17-0396

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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