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Current management of Philadelphia chromosome positive ALL and the role of stem cell transplantation

8 Dec 2017

Abstract excerpt

Abstract Treatment of Philadelphia chromosome positive acute lymphoblastic leukemia exemplifies how the addition of potent targeted agents, directed at the molecular aberrations responsible for leukemic transformation, can overcome resistance mechanisms to traditional regimens and lead to improved outcomes. The introduction of BCR-ABL1 targeted tyrosine kinase inhibitors (TKIs) has significantly improved the...

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Identifiers

PMID: 29222233
DOI: 10.1182/asheducation-2017.1.22

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