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Article

Pro-inflammatory adjuvant properties of pigment-grade titanium dioxide particles are augmented by a genotype that potentiates interleukin 1β processing.

Particle and fibre toxicology - 8 Dec 2017

Riedle Sebastian, Pele Laetitia C, Otter Don E, Hewitt Rachel E, Singh Harjinder, Roy Nicole C, Powell Jonathan J

Abstract excerpt

BACKGROUND: Pigment-grade titanium dioxide (TiO2) particles are an additive to some foods (E171 on ingredients lists), toothpastes, and pharma-/nutraceuticals and are absorbed, to some extent, in the human intestinal tract. TiO2 can act as a modest adjuvant in the secretion of the pro-inflammatory cytokine interleukin 1β (IL-1β) when triggered by common intestinal bacterial fragments, such as lipopolysaccharide...

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Identifiers

PMID: 29216926
DOI: 10.1186/s12989-017-0232-2
PMCID: PMC5721614

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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