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Article

MassARRAY-based simultaneous detection of hotspot somatic mutations and recurrent fusion genes in papillary thyroid carcinoma: the PTC-MA assay.

Endocrine - 1 Jul 2018

Pesenti Chiara, Muzza Marina, Colombo Carla, Proverbio Maria Carla, Farè Claudia, Ferrero Stefano, Miozzo Monica, Fugazzola Laura, Tabano Silvia

Abstract excerpt

PURPOSE: We exploited the MassARRAY (MA) genotyping platform to develop the "PTC-MA assay", which allows the simultaneous detection of 13 hotspot mutations, in the BRAF, KRAS, NRAS, HRAS, TERT, AKT1, PIK3CA, and EIF1AX genes, and six recurrent genetic rearrangements, involving the RET and TRK genes in papillary thyroid cancer (PTC). METHODS: The assay was developed using DNA and cDNA from 12 frozen and 11...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 29214440
DOI: 10.1007/s12020-017-1483-2
PMCID: PMC5997117

Genes

AKT1
BRAF
HRAS
KRAS
NRAS
RET
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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