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Article

Critical and Functional Regulation of CHOP (C/EBP Homologous Protein) through the N-terminal Portion

15 Sept 2007

Abstract excerpt

C/EBP homologous protein (CHOP) is an endoplasmic reticulum stress-inducible protein that plays a critical role in the regulation of programmed cell death; however, the regulation of its function has not been well characterized. We have previously demonstrated that CHOP is regulated by the ubiquitin-proteasome system. In this study, during the process of clarifying the mechanism of the degradation of CHOP, we...

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PMID: 17872950
DOI: 10.1074/jbc.m703735200

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