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Article

Regulation and role of the ER stress transcription factor CHOP in alveolar epithelial type-II cells

25 Apr 2019

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by type-II alveolar epithelial cell (AECII) injury and fibroblast hyperproliferation. Severe AECII endoplasmic reticulum (ER) stress is thought to underlie IPF, but is yet incompletely understood. We studied the regulation of C/EBP homologous protein (CHOP), a proapoptotic ER-stress-related transcription factor (TF) in AECII-like cells....

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PMID: 31025089
DOI: 10.1007/s00109-019-01787-9

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