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Article

LipL21 lipoprotein binding to peptidoglycan enables Leptospira interrogans to escape NOD1 and NOD2 recognition.

PLoS pathogens - 1 Dec 2017

Ratet Gwenn, Santecchia Ignacio, Fanton d'Andon Martine, Vernel-Pauillac Frédérique, Wheeler Richard, Lenormand Pascal, Fischer Frédéric, Lechat Pierre, Haake David A, Picardeau Mathieu, Boneca Ivo G, Werts Catherine

Abstract excerpt

Leptospirosis is a widespread zoonosis, potentially severe in humans, caused by spirochetal bacteria, Leptospira interrogans (L. interrogans). Host defense mechanisms involved in leptospirosis are poorly understood. Recognition of lipopolysaccharide (LPS) and lipoproteins by Toll-Like Receptors (TLR)4 and TLR2 is crucial for clearance of leptospires in mice, yet the role of Nucleotide Oligomerization Domain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29211798
DOI: 10.1371/journal.ppat.1006725
PMCID: PMC5764436

Genes

NOD1
NOD2
TLR2

Provenance

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