Moving beyond microbiome-wide associations to causal microbe identification.

doi:10.1038/nature25019

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Article

Moving beyond microbiome-wide associations to causal microbe identification.

Nature - 14 Dec 2017

Surana Neeraj K, Kasper Dennis L

Abstract excerpt

Microbiome-wide association studies have established that numerous diseases are associated with changes in the microbiota. These studies typically generate a long list of commensals implicated as biomarkers of disease, with no clear relevance to disease pathogenesis. If the field is to move beyond correlations and begin to address causation, an effective system is needed for refining this catalogue of...

Topics

Animals
Body Weight
Cell Survival
Clostridium
Colitis
Feces
Gastrointestinal Microbiome
Germ-Free Life
Intestinal Mucosa
Intestines
Limosilactobacillus reuteri
Mice
Pancreatitis-Associated Proteins
Phenotype
Ruminococcus
Symbiosis

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Identifiers

PMID: 29211710
DOI: 10.1038/nature25019
PMCID: PMC5730484

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