Article
Whole-exome sequencing of sickle cell disease patients with hyperhemolysis syndrome suggests a role for rare variation in disease predisposition.
Transfusion - 1 Mar 2018
Mwesigwa Savannah, Moulds Joann M, Chen Alice, Flanagan Jonathan, Sheehan Vivien A, George Alex, Hanchard Neil A
Abstract excerpt
BACKGROUND: Hyperhemolysis syndrome (HHS) is an uncommon, but life-threatening, transfusion-related complication of red blood cell transfusion. HHS has predominantly been described in patients with sickle cell disease (SCD) and is difficult to diagnose and treat. The pathogenesis of HHS, including its occurrence in only a subset of apparently susceptible individuals, is poorly understood. We undertook whole-exome...
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