Article
Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients.
International journal of cancer - 15 Apr 2018
Koster Roelof, Panagiotou Orestis A, Wheeler William A, Karlins Eric, Gastier-Foster Julie M, Caminada de Toledo Silvia Regina, Petrilli Antonio S, Flanagan Adrienne M, Tirabosco Roberto, Andrulis Irene L, Wunder Jay S, Gokgoz Nalan, Patiño-Garcia Ana, Lecanda Fernando, Serra Massimo, Hattinger Claudia, Picci Piero, Scotlandi Katia, Thomas David M, Ballinger Mandy L, Gorlick Richard, Barkauskas Donald A, Spector Logan G, Tucker Margaret, Belynda D Hicks, Yeager Meredith, Hoover Robert N, Wacholder Sholom, Chanock Stephen J, Savage Sharon A, Mirabello Lisa
Abstract excerpt
Survival rates for osteosarcoma, the most common primary bone cancer, have changed little over the past three decades and are particularly low for patients with metastatic disease. We conducted a multi-institutional genome-wide association study (GWAS) to identify germline genetic variants associated with overall survival in 632 patients with osteosarcoma, including 523 patients of European ancestry and 109 from...
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