Article
Genome-wide association study identifies two susceptibility loci for osteosarcoma.
Nature genetics - 1 Jul 2013
Savage Sharon A, Mirabello Lisa, Wang Zhaoming, Gastier-Foster Julie M, Gorlick Richard, Khanna Chand, Flanagan Adrienne M, Tirabosco Roberto, Andrulis Irene L, Wunder Jay S, Gokgoz Nalan, Patiño-Garcia Ana, Sierrasesúmaga Luis, Lecanda Fernando, Kurucu Nilgün, Ilhan Inci Ergurhan, Sari Neriman, Serra Massimo, Hattinger Claudia, Picci Piero, Spector Logan G, Barkauskas Donald A, Marina Neyssa, de Toledo Silvia Regina Caminada, Petrilli Antonio S, Amary Maria Fernanda, Halai Dina, Thomas David M, Douglass Chester, Meltzer Paul S, Jacobs Kevin, Chung Charles C, Berndt Sonja I, Purdue Mark P, Caporaso Neil E, Tucker Margaret, Rothman Nathaniel, Landi Maria Teresa, Silverman Debra T, Kraft Peter, Hunter David J, Malats Nuria, Kogevinas Manolis, Wacholder Sholom, Troisi Rebecca, Helman Lee, Fraumeni Joseph F, Yeager Meredith, Hoover Robert N, Chanock Stephen J
Abstract excerpt
Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. To better understand the genetic etiology of osteosarcoma, we performed a multistage genome-wide association study consisting of 941 individuals with osteosarcoma (cases) and 3,291 cancer-free adult controls of European ancestry. Two loci achieved genome-wide significance: a locus in the GRM4 gene at 6p21.3 (encoding...
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