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Article

Activating HER2 mutations as emerging targets in multiple solid cancers

1 Jan 2017

Abstract excerpt

The epidermal growth factor receptor (EGFR) family of transmembrane receptor tyrosine kinases activates signalling pathways regulating cellular proliferation and survival. HER2 is a non-ligand-binding member of this family and exerts its activity through heterodimerisation with other EGFR family members. HER2 functional activation promotes oncogenesis, leading to the investigation of HER2-directed agents in...

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PMID: 29209536
DOI: 10.1136/esmoopen-2017-000279

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