Article
Activating HER2 mutations in HER2 gene amplification negative breast cancer.
Cancer discovery - 1 Feb 2013
Bose Ron, Kavuri Shyam M, Searleman Adam C, Shen Wei, Shen Dong, Koboldt Daniel C, Monsey John, Goel Nicholas, Aronson Adam B, Li Shunqiang, Ma Cynthia X, Ding Li, Mardis Elaine R, Ellis Matthew J
Abstract excerpt
UNLABELLED: Data from 8 breast cancer genome-sequencing projects identified 25 patients with HER2 somatic mutations in cancers lacking HER2 gene amplification. To determine the phenotype of these mutations, we functionally characterized 13 HER2 mutations using in vitro kinase assays, protein structure analysis, cell culture, and xenograft experiments. Seven of these mutations are activating mutations, including...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.