Article
Effects of rs958804 and rs7858836 single-nucleotide polymorphisms of the ASTN2 gene on pain-related phenotypes in patients who underwent laparoscopic colectomy and mandibular sagittal split ramus osteotomy.
Neuropsychopharmacology reports - 1 Mar 2021
Inoue Rie, Nishizawa Daisuke, Hasegawa Junko, Nakayama Kyoko, Fukuda Ken-Ichi, Ichinohe Tatsuya, Mieda Tsutomu, Tsujita Miki, Nakagawa Hideyuki, Kitamura Akira, Sumikura Hiroyuki, Ikeda Kazutaka, Hayashida Masakazu
Abstract excerpt
BACKGROUND: Opioids are widely used as effective analgesics, but opioid sensitivity varies widely among individuals. The underlying genetic and nongenetic factors are not fully understood. Based on the results of our previous genome-wide association study, we investigated the effects of single nucleotide polymorphisms (SNPs) of the astrotactin 2 (ASTN2) gene on pain-related phenotypes in surgical patients....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.