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Article

mGluR5 Modulation of Behavioral and Epileptic Phenotypes in a Mouse Model of Tuberous Sclerosis Complex.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 May 2018

Kelly Elyza, Schaeffer Samantha M, Dhamne Sameer C, Lipton Jonathan O, Lindemann Lothar, Honer Michael, Jaeschke Georg, Super Chloe E, Lammers Stephen Ht, Modi Meera E, Silverman Jill L, Dreier John R, Kwiatkowski David J, Rotenberg Alexander, Sahin Mustafa

Abstract excerpt

Drugs targeting metabotropic glutamate receptor 5 (mGluR5) have therapeutic potential in autism spectrum disorders (ASD), including tuberous sclerosis complex (TSC). The question whether inhibition or potentiation of mGluR5 could be beneficial depends, among other factors, on the specific indication. To facilitate the development of mGluR5 treatment strategies, we tested the therapeutic utility of mGluR5 negative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29206810
DOI: 10.1038/npp.2017.295
PMCID: PMC5916364

Genes

PAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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