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Age-associated global DNA hypermethylation augments the sensitivity of hearts towards ischemia-reperfusion injury

15 Nov 2022

Abstract excerpt

Most pre-clinical studies in cardiac ischemia-reperfusion injury (I/R) are carried out in young or old animals, which does not cater to the adult age in humans who encounter I/R. Not many studies in the literature are available that emphasize the sensitivity of the adult heart to injury from the young heart, where there exist distinct alterations in DNA methylation and mitochondrial function that contribute to...

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PMID: 36457746
DOI: 10.3389/fgene.2022.995887

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