Article
A microsatellite repeat in PCA3 long non-coding RNA is associated with prostate cancer risk and aggressiveness.
Scientific reports - 4 Dec 2017
Lai John, Moya Leire, An Jiyuan, Hoffman Andrea, Srinivasan Srilakshmi, Panchadsaram Janaththani, Walpole Carina, Perry-Keene Joanna L, Chambers Suzanne, Lehman Melanie L, Nelson Colleen C, Clements Judith A, Batra Jyotsna
Abstract excerpt
Short tandem repeats (STRs) are repetitive sequences of a polymorphic stretch of two to six nucleotides. We hypothesized that STRs are associated with prostate cancer development and/or progression. We undertook RNA sequencing analysis of prostate tumors and adjacent non-malignant cells to identify polymorphic STRs that are readily expressed in these cells. Most of the expressed STRs in the clinical samples...
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