Article
Association of short tandem repeat polymorphism in the promoter of prostate cancer antigen 3 gene with the risk of prostate cancer.
PloS one - 1 Jan 2011
Zhou Wu, Chen Zhanguo, Hu Wangqiang, Shen Mo, Zhang Xiaoxia, Li Chengdi, Wen Zhiliang, Wu Xiuling, Hu Yuanping, Zhang Xiaohua, Duan Xiuzhi, Han Xiucui, Tao Zhihua
Abstract excerpt
BACKGROUND: PCA3 (prostate cancer antigen 3) gene is one of the most prostate cancer-specific genes at present. Consequently, the prostate-specific expression and the sharp up-regulation of PCA3 mRNA in prostate cancer suggest a unique transcriptional regulation, which possibly can be attributed to promoter polymorphism. In our study, we evaluated whether there is polymorphism in PCA3 promoter region and also...
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