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Article

Chromatin mediation of a transcriptional memory effect in yeast.

G3 (Bethesda, Md.) - 5 Mar 2015

Paul Emily, Tirosh Itay, Lai William, Buck Michael J, Palumbo Michael J, Morse Randall H

Abstract excerpt

Previous studies have described a transcriptional "memory effect," whereby transcript levels of many Abf1-regulated genes in the budding yeast Saccharomyces cerevisiae are undiminished even after Abf1 has dissociated from its regulatory sites. Here we provide additional support for this effect and investigate its molecular basis. We show that the effect is observed in a distinct abf1 ts mutant from that used in...

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Identifiers

PMID: 25748434
DOI: 10.1534/g3.115.017418
PMCID: PMC4426369

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