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Article

Endothelial progenitor cells give rise to pro-angiogenic smooth muscle-like progeny.

Cardiovascular research - 1 Jun 2010

Moonen Jan-Renier A J, Krenning Guido, Brinker Marja G L, Koerts Jasper A, van Luyn Marja J A, Harmsen Martin C

Abstract excerpt

AIMS: Reciprocal plasticity exists between endothelial and mesenchymal lineages. For instance, mature endothelial cells adopt a smooth muscle-like phenotype through transforming growth factor beta-1 (TGFbeta1)-driven endothelial-to-mesenchymal transdifferentiation (EndMT). Peripheral blood contains circulating endothelial progenitor cells of which the endothelial colony-forming cells (ECFCs) harbour stem...

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PMID: 20083576
DOI: 10.1093/cvr/cvq012

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