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The Alzheimer's Disease Sequencing Project: Study design and sample selection

1 Oct 2017

Abstract excerpt

Late-onset Alzheimer disease (LOAD) is the leading cause of dementia worldwide, with substantial economic and public health implications.1 LOAD is a neurodegenerative disease characterized by progressive dementia typically manifesting in the seventh to ninth decades. Neuropathological changes precede clinical symptoms by 10–20 years, resulting in clinically asymptomatic individuals carrying neuropathologic...

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PMID: 29184913
DOI: 10.1212/nxg.0000000000000194

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