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Prediction of gene cluster function based on transcriptional regulatory networks uncovers a novel locus required for desferrioxamine B biosynthesis

2024-06-11

Abstract excerpt

<h4>ABSTRACT</h4> Bacteria produce a plethora of natural products that are in clinical, agricultural and biotechnological use. Genome mining revealed millions of biosynthetic gene clusters (BGCs) that encode their biosynthesis, and the major challenge is to predict the bioactivities of the molecules these BGCs specify, and how to elicit their expression. Here, we present an innovative strategy whereby we harness...

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Literature Corpus work
0f9b7703-e9bb-5915-b638-ef1963ec6c83
DOI
10.1101/2024.06.10.598258
Open publication

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Prediction of gene cluster function based on transcriptional regulatory networks uncovers a novel locus required for desferrioxamine B biosynthesisDOI 10.1101/2024.06.10.598258
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