Article
Conformational selection guides β-arrestin recruitment at a biased G protein-coupled receptor.
Science (New York, N.Y.) - 8 Jul 2022
Kleist Andrew B, Jenjak Shawn, Sente Andrija, Laskowski Lauren J, Szpakowska Martyna, Calkins Maggie M, Anderson Emilie I, McNally Lisa M, Heukers Raimond, Bobkov Vladimir, Peterson Francis C, Thomas Monica A, Chevigné Andy, Smit Martine J, McCorvy John D, Babu M Madan, Volkman Brian F
Abstract excerpt
G protein-coupled receptors (GPCRs) recruit β-arrestins to coordinate diverse cellular processes, but the structural dynamics driving this process are poorly understood. Atypical chemokine receptors (ACKRs) are intrinsically biased GPCRs that engage β-arrestins but not G proteins, making them a model system for investigating the structural basis of β-arrestin recruitment. Here, we performed nuclear magnetic...
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