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Article

Identification of DmTTLL5 as a Major Tubulin Glutamylase in the Drosophila Nervous System.

Scientific reports - 24 Nov 2017

Devambez Isabelle, van Dijk Juliette, Benlefki Salim, Layalle Sophie, Grau Yves, Rogowski Krzysztof, Parmentier Marie-Laure, Soustelle Laurent

Abstract excerpt

Microtubules (MTs) play crucial roles during neuronal life. They are formed by heterodimers of alpha and beta-tubulins, which are subjected to several post-translational modifications (PTMs). Amongst them, glutamylation consists in the reversible addition of a variable number of glutamate residues to the C-terminal tails of tubulins. Glutamylation is the most abundant MT PTM in the mammalian adult brain,...

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Identifiers

PMID: 29176602
DOI: 10.1038/s41598-017-16586-w
PMCID: PMC5701211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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