Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular modeling study on resistance of WT/D473H SMO to antagonists LDE-225 and LEQ-506.

Pharmacological research - 1 Mar 2018

Tu Jing, Li Jiao Jiao, Song Li Ting, Zhai Hong Lin, Wang Juan, Zhang Xiao Yun

Abstract excerpt

The smoothened (SMO) receptor, an essential signal transducer in the Hedgehog pathway, was targeted with antagonists to suppress the tumor. It is interesting that SMO D473H mutation confers resistance on inhibitor LDE-225 rather than LEQ-506. In this paper, the binding modes of them against the wild type and mutant SMO receptors were identified to gain insights into the resistant and non-resistant factors, based...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biphenyl Compounds
Share to Drug Resistance
Share to SMO gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ligands

Share to Models, Molecular

Share to Mutation

Share to Pyridines

Share to Smoothened Receptor

Source

Identifiers

PMID: 29175550
DOI: 10.1016/j.phrs.2017.11.025

Genes

SMO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular modeling study on resistance of WT/D473H SMO to antagonists LDE-225 and LEQ-506.PMID 29175550Read ↗

Analysis of vismodegib resistance in D473G and W535L mutants of SMO receptor and design of novel drug derivatives using molecular dynamics simulations.Semantic proximity Read ↗

Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened.Semantic proximity Read ↗

Biochemical characterization of smoothened receptor antagonists by binding kinetics against drug-resistant mutant.Semantic proximity Read ↗

Cyclopamine modulates smoothened receptor activity in a binding position dependent manner.Semantic proximity Read ↗

Design of Hedgehog pathway inhibitors for cancer treatmentSemantic proximity Read ↗

Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance.Semantic proximity Read ↗

Structural insights into the mechanism of resistance to bicalutamide by the clinical mutations in androgen receptor in chemo-treatment resistant prostate cancer.Semantic proximity Read ↗

A Molecular Modeling Study of the Hydroxyflutamide Resistance Mechanism Induced by Androgen Receptor Mutations.Semantic proximity Read ↗

MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor.Semantic proximity Read ↗

Inhibition mechanism exploration of investigational drug TAK-441 as inhibitor against Vismodegib-resistant Smoothened mutant.Semantic proximity Read ↗

Molecular Dynamics Studies on the Enzalutamide Resistance Mechanisms Induced by Androgen Receptor MutationsSemantic proximity Read ↗

Smoothened variants explain the majority of drug resistance in basal cell carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.