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Article

Cyclopamine modulates smoothened receptor activity in a binding position dependent manner.

Communications biology - 28 Sept 2024

Kim Kihong, Bansal Prateek D, Shukla Diwakar

Abstract excerpt

Cyclopamine, a natural alkaloid, can act as an agonist when it binds to the Cysteine-Rich Domain (CRD) of Smoothened receptor and as an antagonist when it binds to the Transmembrane Domain (TMD). To study the effect of cyclopamine binding to each site experimentally, mutations in the other site are required. Hence, simulations are critical for understanding the WT activity due to binding at different sites. Using...

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Identifiers

PMID: 39342033
DOI: 10.1038/s42003-024-06906-y
PMCID: PMC11438977

Genes

SMO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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