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Article

Re-evaluating the role of FOXOs in cancer

22 Nov 2017

Abstract excerpt

FOXO transcription factors are negatively regulated by the PI3K-PKB/AKT signaling pathway and have been mainly considered to be tumor suppressors due to their inhibitory effect on cancer cell growth and survival. However, FOXOs can also support tumor development and progression by maintaining cellular homeostasis, facilitating metastasis and inducing therapy resistance. In agreement with these opposing views on...

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Identifiers

PMID: 29175105
DOI: 10.1016/j.semcancer.2017.11.017

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