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Article

Myricetin Reduces Toxic Level of CAG Repeats RNA in Huntington's Disease (HD) and Spino Cerebellar Ataxia (SCAs).

ACS chemical biology - 19 Jan 2018

Khan Eshan, Tawani Arpita, Mishra Subodh Kumar, Verma Arun Kumar, Upadhyay Arun, Kumar Mohit, Sandhir Rajat, Mishra Amit, Kumar Amit

Abstract excerpt

Huntington's disease (HD) is a neurodegenerative disorder that is caused by abnormal expansion of CAG repeats in the HTT gene. The transcribed mutant RNA contains expanded CAG repeats that translate into a mutant huntingtin protein. This expanded CAG repeat also causes mis-splicing of pre-mRNA due to sequestration of muscle blind like-1 splicing factor (MBNL1), and thus both of these elicit the pathogenesis of...

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Source

Identifiers

PMID: 29172480
DOI: 10.1021/acschembio.7b00699

Genes

MBNL1
HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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