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Mechanisms of RNA-induced toxicity in CAG repeat disorders

1 Aug 2013

Abstract excerpt

Several inherited neurodegenerative disorders are caused by CAG trinucleotide repeat expansions, which can be located either in the coding region or in the untranslated region (UTR) of the respective genes. Polyglutamine diseases (polyQ diseases) are caused by an expansion of a stretch of CAG repeats within the coding region, translating into a polyQ tract. The polyQ tract expansions result in conformational...

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PMID: 23907466
DOI: 10.1038/cddis.2013.276

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