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Article

Hypermethylation and loss of retinoic acid receptor responder 1 expression in human choriocarcinoma

23 Nov 2017

Abstract excerpt

BACKGROUND: Human placental development resembles tumorigenesis, due to the invasive and fusogenic potential of trophoblasts. However, these features are tightly controlled in trophoblasts. Disturbance of this spatial and temporal regulation is thought to contribute to the rare formation of choriocarcinomas. Promoter hypermethylation and loss of the tumor suppressor Retinoic acid receptor responder 1 (RARRES1)...

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PMID: 29169400
DOI: 10.1186/s13046-017-0634-x

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