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Article

Primary tumor location predicts poor clinical outcome with cetuximab in RAS wild-type metastatic colorectal cancer.

BMC gastroenterology - 23 Nov 2017

Kim Dalyong, Kim Sun Young, Lee Ji Sung, Hong Yong Sang, Kim Jeong Eun, Kim Kyu-Pyo, Kim Jihun, Jang Se Jin, Yoon Young-Kwang, Kim Tae Won

Abstract excerpt

BACKGROUND: In metastatic colorectal cancer, the location of the primary tumor has been suggested to have biological significance. In this study, we investigated whether primary tumor location affects cetuximab efficacy in patients with RAS wild-type metastatic colorectal cancer. METHODS: Genotyping by the SequenomMassARRAY technology platform (OncoMap) targeting KRAS, NRAS, PIK3CA, and BRAF was performed in...

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Identifiers

PMID: 29169325
DOI: 10.1186/s12876-017-0694-6
PMCID: PMC5701369

Genes

BRAF
KRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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