Article
Protein O-Mannosyltransferases Affect Sensory Axon Wiring and Dynamic Chirality of Body Posture in the Drosophila Embryo.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 14 Feb 2018
Baker Ryan, Nakamura Naosuke, Chandel Ishita, Howell Brooke, Lyalin Dmitry, Panin Vladislav M
Abstract excerpt
Genetic defects in protein O-mannosyltransferase 1 (POMT1) and POMT2 underlie severe muscular dystrophies. POMT genes are evolutionarily conserved in metazoan organisms. In Drosophila, both male and female POMT mutants show a clockwise rotation of adult abdominal segments, suggesting a chirality of underlying pathogenic mechanisms. Here we described and analyzed a similar phenotype in POMT mutant embryos that...
Topics
- Animals
- Animals, Genetically Modified
- Axons
- Drosophila Proteins
- Dystroglycans
- Embryo, Nonmammalian
- Feedback, Physiological
- Mannosyltransferases
- Muscle Contraction
- Mutation
- Peripheral Nervous System
- Phenotype
- Posture