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Article

Neurexin facilitates glycosylation of Dystroglycan to sustain muscle architecture and function in Drosophila.

Communications biology - 9 Nov 2024

Zhao Yu, Geng Junhua, Meng Zhu, Sun Yichen, Ou Mengzhu, Xu Lizhong, Li Moyi, Gan Guangming, Rui Menglong, Han Junhai, Xie Wei

Abstract excerpt

Neurexin, a molecule associated with autism spectrum disorders, is thought to function mainly in neurons. Recently, it was reported that Neurexin is also present in muscle, but the role of Neurexin in muscle is still poorly understood. Here, we demonstrate that the overexpression of Neurexin in muscles effectively restored the locomotor function of Drosophila neurexin mutants, while rescuing effects are observed...

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Share to Cell Adhesion Molecules, Neuronal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39521920
DOI: 10.1038/s42003-024-07191-5
PMCID: PMC11550397

Genes

POMT1

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