Article
Production and rearing of germ-free X-SCID pigs.
Experimental animals - 10 May 2018
Hara Hiromasa, Shibata Hiroaki, Nakano Kazuaki, Abe Tomoyuki, Uosaki Hideki, Ohnuki Takahiro, Hishikawa Shuji, Kunita Satoshi, Watanabe Masahito, Nureki Osamu, Nagashima Hiroshi, Hanazono Yutaka
Abstract excerpt
Pigs with X-linked severe combined immunodeficiency (X-SCID) caused by a mutation of the interleukin-2 receptor gamma chain gene (IL2RG) are of value for a wide range of studies. However, they do not survive longer than 8 weeks because of their susceptibility to infections. To allow longer survival of X-SCID pigs, the animals must be born and reared under germ-free conditions. Here, we established an efficient...
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