Article
Repeat polymorphisms in the Homo sapiens heme oxygenase-1 gene in diabetic and idiopathic gastroparesis.
PloS one - 1 Jan 2017
Gibbons Simon J, Grover Madhusudan, Choi Kyoung Moo, Wadhwa Akhilesh, Zubair Adeel, Wilson Laura A, Wu Yanhong, Abell Thomas L, Hasler William L, Koch Kenneth L, McCallum Richard W, Nguyen Linda A B, Parkman Henry P, Sarosiek Irene, Snape William J, Tonascia James, Hamilton Frank A, Pasricha Pankaj J, Farrugia Gianrico
Abstract excerpt
BACKGROUND: Idiopathic and diabetic gastroparesis in Homo sapiens cause significant morbidity. Etiology or risk factors have not been clearly identified. Failure to sustain elevated heme oxygenase-1 (HO1) expression is associated with delayed gastric emptying in diabetic mice and polymorphisms in the HO1 gene (HMOX1, NCBI Gene ID:3162) are associated with worse outcomes in other diseases. AIM: Our hypothesis was...
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