Article

NPC1 deficiency engages a lysosome–genome–immune program linked to neurodegeneration and cellular aging signatures

2026-07-13

Abstract excerpt

<h4>ABSTRACT</h4> Lysosomal dysfunction is a prominent feature of neurodegeneration and aging, yet how primary defects in lysosomal trafficking are converted into progressive cellular decline remains poorly understood. Niemann Pick disease type C (NPC), caused by impaired NPC1 dependent cholesterol export, provides a genetically defined model to address this question. Here, we show that NPC1 deficiency activates...

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Literature Corpus work: aabe457d-0331-5569-a574-f5e81d8c1051
DOI: 10.64898/2026.07.12.738054

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