Article
The ex vivo toll-like receptor 7 tolerance induction in donor lymphocytes prevents murine acute graft-versus-host disease.
Cytotherapy - 1 Jan 2018
Zogas Nikolaos, Karponi Garyfalia, Iordanidis Fotios, Malasidis Stylianos, Paraskevas Vasilios, Papadopoulou Anastasia, Scouras Zaharias George, Anagnostopoulos Achilles, Yannaki Evangelia
Abstract excerpt
BACKGROUND AIMS: Acute graft-versus-host disease (aGVHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation, mediated by alloreactive donor T cells. Toll-like receptors (TLRs), a family of conserved pattern-recognition receptors (PRRs), represent key players in donors' T-cell activation during aGVHD; however, a regulatory, tolerogenic role for certain TLRs...
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