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Chimerism-Based Tolerance to Kidney Allografts in Humans: Novel Insights and Future Perspectives

5 Jan 2022

Abstract excerpt

Chronic rejection and immunosuppression-related toxicity severely affect long-term outcomes of kidney transplantation. The induction of transplantation tolerance - the lack of destructive immune responses to a transplanted organ in the absence of immunosuppression - could potentially overcome these limitations. Immune tolerance to kidney allografts from living donors has been successfully achieved in humans...

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Identifiers

PMID: 35069574
DOI: 10.3389/fimmu.2021.791725

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