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Article

Mutation-Induced Deamidation of Corneal Dystrophy-Related Transforming Growth Factor β-Induced Protein.

Biochemistry - 12 Dec 2017

Nielsen Nadia Sukusu, Juhl Dennis Wilkens, Poulsen Ebbe Toftgaard, Lukassen Marie V, Poulsen Emil Christian, Risør Michael W, Scavenius Carsten, Enghild Jan J

Abstract excerpt

Mutations in the transforming growth factor β-induced protein (TGFBIp) cause phenotypically diverse corneal dystrophies, where protein aggregation in the cornea leads to severe visual impairment. Previous studies have shown a relationship between mutant-specific corneal dystrophy phenotypes and the thermodynamic stability of TGFBIp. Using liquid chromatography-tandem mass spectrometry and nuclear magnetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29140698
DOI: 10.1021/acs.biochem.7b00668

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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