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Article

Suppression of Activated FOXO Transcription Factors in the Heart Prolongs Survival in a Mouse Model of Laminopathies.

Circulation research - 2 Mar 2018

Auguste Gaelle, Gurha Priyatansh, Lombardi Raffaella, Coarfa Cristian, Willerson James T, Marian Ali J

Abstract excerpt

RATIONALE: Mutations in the LMNA gene, encoding nuclear inner membrane protein lamin A/C, cause distinct phenotypes, collectively referred to as laminopathies. Heart failure, conduction defects, and arrhythmias are the common causes of death in laminopathies. OBJECTIVE: The objective of this study was to identify and therapeutically target the responsible mechanism(s) for cardiac phenotype in laminopathies....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29317431
DOI: 10.1161/CIRCRESAHA.117.312052
PMCID: PMC5834384

Genes

FOXO1
LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Suppression of Activated FOXO Transcription Factors in the Heart Prolongs Survival in a Mouse Model of Laminopathies.PMID 29317431Read ↗

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